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Transmission

Annick Sartenaer, Full Professor - Alexandre Mauroy, Professor - Nicolas Franco, Ph. D. - Sébastien Clesse, Ph. D.- Morgane Dumont, Ph.D. Student

UNamur - FNRS
" Professors and researches from the Department of Mathematics and the naXys research institute of complex systems at UNamur gathered their skills and expertise in mathematical modeling, dynamic systems, statistics, control theory and numerical optimization to develop prediction and unlockdown monitoring models of the Covid-19 epidemic. They set up a consortium in mathematical modeling of the Covid-19 epidemic bringing together all the universities of the Wallonia Brussels Federation, in synergy with its equivalent in Flanders. "
Contact: Annick Sartenaer (This email address is being protected from spambots. You need JavaScript enabled to view it.) Alexandre Mauroy (This email address is being protected from spambots. You need JavaScript enabled to view it.) Nicolas Franco (This email address is being protected from spambots. You need JavaScript enabled to view it.) Sébastien Clesse (This email address is being protected from spambots. You need JavaScript enabled to view it.) Morgane Dumont (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Caroline Daelemans, Professor

ULB
" COVerT Our aim is to delineate more accurately the prevalence of the infection in the pregnant population and study vertical transmission in the cord blood of babies born to mothers with confirmed SARS-CoV-2 infection. Determination of prevalence of SARS-CoV-2 infection in mothers by combined universal screening: presence of antibodies (IgG and IgM or IgA) in their blood and/or a positive RT-PCR in the nasopharyngeal swab. We intend to detect evidence of vertical transmission by the identification of SARS-CoV-2 specific IgM or IgA in cord blood samples. If there is evidence of vertical transmission, the analysis of the consequences depending on infection timing during pregnancy will enable us to guide management more precisely. "
Funding: pending FNRS
Publication References: "1. Delforge ML, Costa E, Brancart F, Goldman D, Montesinos I, Zaytouni S, Marchant A, Donner C Presence of cytomegalovirus in urine and blood of pregnant women with primary infection might be associated...

Denis Terwagne, Professor - Victor Lévy, Professor - Alain Delchambre, Professor - Nicolas De Coster

ULB - Fablab ULB
" A multidisciplinary team at the Fablab ULB (Université Libre de Bruxelles, Belgium) has developed and produced different open-source emergency protective solutions against Covid-19 for hospitals and caregivers. Most of these solutions have been developed within the global fablab network using digital fabrication machines (laser cutter, 3D printers,...) and open-source documentation which allowed other fablabs in the world to develop and produced these solutions locally. Face Protective Masks Face Protective Masks have been developed to protect caregivers from aerosol projection. Thanks to a lot of help (other fablabs, architectural offices, students, volunteers,...), we have produced more than 50 000 Protective Face Shields and distributed them in hospitals and to other caregivers. This project was made in collaboration with Fab-C (Charleroi), fablab Yourlab (Andenne) and the Hospital CHU Saint-Pierre in Brussels and supported by the Michel Crémer Foundation. Swabs...

François Reniers, Professor - Carine Van Lint, FNRS Research Director - Anne Op De Beeck, Professor

ULB - FNRS
" Because of the persistence of viruses on surfaces, they represent Indirect transmission vectors of diseases. If many antibacterial surfaces exist, virucidal surfaces are more challenging. This project aims at developping Superior virucidal surfaces. This project is a collaboration between the ChemSIN (synthesis of surfaces), the laboratory of Molecular virology and the Centre for Diabetes Research of ULB "
Funding: ULB Walloon Region (requested) FNRS (requested)
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François Reniers, Professor - Carine Van Lint, FNRS Research Director - Anne Op De Beeck, Professor

ULB - FNRS
" Inactivation of viruses on surfaces, textiles, surgical Tools, or any 2D or 3D object cannot always be performed using chemicals. This project aims at inactivating viruses using various atmospheric plasma sources, and study these mechanisms of inactivation. "
Funding: ULB Walloon Region (requested)
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François Roland- Martin Waroux - Elodie Wannez - Delphine Dauby

UMONS ; FabLab Mons ; Fab-C Charleroi Métropole ; FabLab Wapi
" Visors for face masks produced at FabLab Mons. In collaboration with Fab-C Charleroi Métropole and FabLab Wapi, FabLab Mons is currently producing visors for nursing staff. These visors extend the life of the masks by preventing splash contamination. This has been made possible with the financial support of the FRMH and the donation of transparent sheets from multiple organisations, which has enabled the FabLab to distribute several thousand visors (23,000+ distributed to date) to medical doctors, nurses, pharmacists, physiotherapists, nursing home staff, opticians and audiologists. "
Contact: FabLab Mons https://fablabmons.be This email address is being protected from spambots. You need JavaScript enabled to view it.

Jean-Paul Deslypere, MD

Aesculape CRO Belgium BV
" Treatment of COVID 19 complications with antibodies "
Funding: partly public partly private
Contact : This email address is being protected from spambots. You need JavaScript enabled to view it. 0492 735931

Keith Durkin, Dr - Maria Artesi, Dr - Sébastien Bontems, Dr - Marie-Pierre Hayette, Dr- Vincent Bours, Dr

ULiège
" Since SARS-CoV-2 testing began at the CHU of Liège we have been carrying out regular whole genome sequencing (WGS) of COVID-19 samples. At the time of writing we have uploaded 187 viral genomes to https://nextstrain.org/ (almost half of the 393 from Belgium). We have carried out regular WGS to monitor the evolution of viral haplotypes. Where possible we have concentrated on health care workers with the goal of identifying clusters of transmission. This included a cluster of seven individuals who were tested on the Roche cobas® instrument using the SARS-CoV-2 test, all were positive for the ORF1ab assay, but negative for the second E-gene assay. To date we have WGS data from four of these individuals, all share identical viral genomes and a SNP in the E-gene has been identified as the most probable cause of the test failure. This observation highlights the importance of redundancy in SARS-CoV-2 assays, especially as some testing regimes recommend an E-gene assay as a primary...

Michelle Nisolle, Professor - Vincent Rigo, Professor - Katty Delbecque, Doctor

ULiège, CHU, Obstetrics and Gynecology - Royal Academy of Medicine of Belgium
" The primary objective of the project is to assess the risk of maternal-fetal transmission of the SARS-CoV-2 virus. The secondary objectives are to analyze the impact of COVID-19 infection on the course of pregnancy as well as that of the newborn. This is a prospective study of a positive COVID-19 pregnant patients cohort in a population of 2,500 patients who give birth in the Gynecology-Obstetrics Department at CHR-Liège. Samples will be taken from the mother, the newborn and from the placenta during childbirth from patients who were diagnosed with COVID-19 during pregnancy or when they were admitted to the delivery unit. Obstetric and neonatal repercussions will be analyzed. "
Funding: Fondation Leon Fredericq
Contact: Pr Michelle Nisolle This email address is being protected from spambots. You need JavaScript enabled to view it.

O. Vandenberg, Pr. - N. Clumeck, Pr. - C. Montesinos, Pr. - N. Dauby, MD, PhD - C. Gilles, MD - C. Martin, MD - S. Van den Wijngaert, MD - A. Marchant, Pr. - D. Martiny, Pr. - S. De Wit, Pr.

LHUB-ULB - Royal Academy of Medicine of Belgium
" "The purpose of this study is to map the healthcare workers exposure risk in Saint-Pierre University Hospital by combining molecular methods with serological assays. In summary, the short-term objective is threefold: (1) Provide an estimate of the sero-prevalence at baseline among high-risk health care workers (2) Determine prospectively the incidence of new SARS-CoV-2 infections among high-risk health care workers (3) Estimate the healthcare worker exposure to the virus by serological data to help our five partner hospitals in their day-to-day management of the ongoing pandemic The mid-term objectives are: (1) Establish an accurate mapping of the spread of the virus among our population allowing to identify the chain of transmission, (2) Identify predictive immunological markers of susceptibility to infection and disease severity to inform vaccine strategies and, (3) Establish solid diagnosis algorithm that will help adequate lockdown...

Philippe Denoel, Head of External R&D

GSK - Royal Academy of Medicine of Belgium
" Support covid international: https://www.gsk.com/en-gb/media/resource-centre/our-contribution-to-the-fight-against-2019-ncov/ Support covid en Belgique: https://be.gsk.com/media/915368/cp-gsk-contributions-majeures-de-gsk-a-la-lutte-contre-le-covid-19.pdf NA NA "
Funding: NA
Contact: Philippe Denoel - This email address is being protected from spambots. You need JavaScript enabled to view it.

Pierre Smeesters, Professor

HUDERF and ULB
" Role of Children in Sars-Cov-2 transmission, Heath Care Worker protection, Paediatric epidemiology and disease burden "
Funding: FNRS funding under assessment.
Contact: Prof Pierre Smeesters Academic Children Hospital Queen Fabiola Molecular Bacteriology Laboratory, ULB This email address is being protected from spambots. You need JavaScript enabled to view it.

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Brussels & Wallonia against COVID19