CHU of Liège
" The aim of this study is to search for the presence of antibodies against SARS-CoV-2 in the staff of CHU de Liège and University of Liège, and to follow the evolution of antibody levels on blood samples taken 1.5 and 3 months after the first sample. This will allow to : • carry out a COVID-19 seroprevalence study by assaying anti-SARS-CoV-2 antibodies in people in contact with patients, compared to a population of "negative control" subjects, at baseline and 1.5 and 3 months after the first testing ; • observe the evolution of antibody levels between samples; • highlight possible seroconversion between samples in asymptomatic persons "
Funding: Wallonia Region CHU of Liège University of Liège Fondation Léon Frédéricq
Contact: Dr Pascale Huynen, Dpt of Clinical Microbiology, CHU of Liège and University of Liège Prof Pierrette Melin, Dpt of Clinical Microbiology, CHU of Liège and University of Liège Prof Yves Beguin, Dpt of Hematology, CHU of Liège and University of...

Read more: Pascale Huynen, Dr

Cliniques universitaires Saint-Luc, UCLouvain
" The objective of our project is to describe the nasopharyngeal (NP) microbiota and virome of SARS-CoV-2 infected patients at diagnosis through unbiased nextgeneration sequencing analysis and to correlate microbiota and virome profile with COVID-19 infectious phenotype. At a second stage of our project, provided additional findings are raised, those data will be enriched by NP transcriptome analysis of infected patients, and background genomic determination. Integration of those data and analysis through systems biology approach will enable better understanding of multidirectional host-pathogen interactions. "
Funding: FNRS CUR requested. Additional funding will be requested for further steps.
Contact: Pr L.Belkhir This email address is being protected from spambots. You need JavaScript enabled to view it. 02/7642198 --- Pr P.Cani This email address is being protected from spambots. You need JavaScript enabled to view it.

UCLouvain
" We are designing bacteria that produces the essential protease of COVID-19 and whose activity is associated with sensitivity to a specific antibiotics. This bacteria is a powerful platform for screening potential inhibitors of the protease (the bacteria becomes resistant to the antibiotics if the protease is inhibited). We will use it to screen large combinatorial libraires of cyclic peptides that will be produced by the bacteria as well. "
Funding: Lab funds. FRNS grant application ongoing.
Contact: Patrice Soumillion Louvain Institute of Biomolecular Science and Technology, UCLouvain Place Croix du Sud 4-5 1348 Louvain-la-Neuve

Aseptic Technologies SA
" Table-top equipment for FFP2 mask decontamination by means of UV-C, developed jointly by Lasea s.a. and Aseptic Technologies s.a. Allows re-use of FFP2 masks up to 5 times (under validation process) "
Contact: Patrick Baleriaux CEO Aseptic Technologies s.a This email address is being protected from spambots. You need JavaScript enabled to view it.

Malcourant Mécanique
" We have developed a semi-automatic machine to weld polyethylene sheets in order to make the COVID-19 protective mask envelope. This development has been carried out entirely in-house, study - manufacture - assembly. We called the company ICS to improve the working conditions for the welding jaws. "
Contact: malcourant-mecanique.be incosol4u.com

ULiège. ULiège Library
" In order to highlight the Open Access research published by our scholars, ULiège Library has launched a harvesting project (called "Mosa") of existing Belgian and Luxembourgish Open Access publication platforms and academic bibliographies. Mosa aims to act as an aggregator of institutional and federal publication platforms. At this time, Mosa harvests more than 10 repositories from KCE, KU Leuven, UAntwerp, UCLouvain, UGent, ULB, ULiège, UNamur, Unilu, and USL-B on a daily basis. To get integrated into Mosa, harvested records need to have at least one full text in open access or in restricted access. Mosa contains more than 590,000 records (327,000 research articles, 66,000 proceedings, 47,000 dissertations, 40,000 lectures and posters, 35,000 book chapters…). A dedicated search slot containing only Belgian and Luxembourgish research publications and communications around COVID-19 has been created within Mosa. "
Contact: Paul Thirion &lt...

Read more: Paul Thirion, Chief Librarian - François Renaville, Head of Library Systems

ULiège, CHU - Royal Academy of Medicine of Belgium
" Nous faisons face à une pandémie d'infection COVID-19. Ce virus pathogène est source de complications pulmonaires aggravant fortement le pronostic de nos patients. De nos jours, tant les mécanismes physiopathologiques en cause que les marqueurs de sévérité de l'atteinte restent indéterminés. Il apparaît donc comme urgent de pouvoir identifier des marqueurs diagnostiques, pronostiques et prédictifs pour nos patients. Dans ce contexte, plusieurs voies rapidement explorables nous apparaissent comme critiques. Le but final de cette étude est de contribuer à une prise en charge plus ciblée des patients porteurs d'une infection au SRAS-Cov-2. "
Funding: Fonds Léon Frederic
Publication References: Dix publications représentatives : 1) Prevention of murine radiogenic thymic lymphomas by tumor necrosis factor or by marrow grafting. HUMBLET C, GREIMERS R, DELVENNE P, DEMAN J, BONIVER J, DEFRESNE MP. J Natl Cancer Inst 88 (1996), 824-831. IF...

Read more: Ph. DELVENNE, FNRS Research Director / Chef de service Anatomie pathologique - J. GUIOT, Chef de...

ULB
" We developed a sensor network system that estimates and forecasts crowd counts in outdoor and indoor areas. The counts and forecasts are available in real-time through a web service. The system allows authorities and owners to manage and control social distancing measures. The system is ready for installation and use. "
Publication References: J-F Determe, U. Singh, F.Horlin, Ph De Doncker, « Forecasting Crowd Counts With Wi-Fi Systems: Univariate, Non-Seasonal Models », IEEE Transactions on Intelligent Transportation Systems, 2020
Contact: Prof. François Horlin (This email address is being protected from spambots. You need JavaScript enabled to view it.) Prof. Philippe De Doncker (This email address is being protected from spambots. You need JavaScript enabled to view it.)

GSK - Royal Academy of Medicine of Belgium
" Support covid international: https://www.gsk.com/en-gb/media/resource-centre/our-contribution-to-the-fight-against-2019-ncov/ Support covid en Belgique: https://be.gsk.com/media/915368/cp-gsk-contributions-majeures-de-gsk-a-la-lutte-contre-le-covid-19.pdf NA NA "
Funding: NA
Contact: Philippe Denoel - This email address is being protected from spambots. You need JavaScript enabled to view it.

ULB, UR2NF - Neuropsychology and Functional Neuroimaging Research Unit affiliated at CRCN - Center for Research in Cognition and Neurosciences and UNI - ULB Neurosciences Institute - FNRS - Royal Academy of Sciences, Letters and Fine Arts of Belgium
" The aim of the study is to examine day-to-day associations between subjective sleep quality and daytime functioning during the large-scale confinement measures taken in Belgium given the current Covid-19 pandemic in Europe. In particular, we are interested in assessing the interplay between altered patterns of sleep timing, duration and quality, and daytime behaviour, cognition, and affect for 2 weeks during the confinement period. Longitudinal data are obtained in Belgium, Hungary and Spain "
Funding: internal resources
Publication References: ongoing project
Contact: Project : This email address is being protected from spambots. You need JavaScript enabled to view it., Peter Simor: This email address is being protected from spambots. You need JavaScript enabled to view it. Philippe Peigneux : This email address is being protected from spambots. You need JavaScript enabled to view it.

GIGA-Institute, ULiège - FNRS
" In this project, we study the epitranscriptomic regulation of the SARS-CoV-2. Based on analyses of the viral genome, we investigate the cellular machineries required for the viral replicative cycle. Our goal is to identify possible viral vulnerabilities that can be exploited for the development of innovative anti-viral therapeutic strategies. We investigate possible new therapeutic opportunities based on the analyses of the viral genomic organization and evolution. We speculate that specific cellular machineries are needed to support the viral replicative cycle. Our goal is uncover new antiviral therapeutic strategies based on the viral epitranscriptomic regulation, mRNA translation and protein expression. "
Funding: WELBIO & ULIEGE
Publication References: Rapino F, Delaunay S, Rambow F, Zhou Z, Tharun L, De Tullio P, Sin O, Shostak, Schmitz S, Piepers J, Ghesquière B, Karim L, Charloteaux B, Jamart D, Florin A, Lambert C, Rorive A, Jerusalem G...

Read more: Pierre CLOSE, FNRS Research Associate - Francesca RAPINO, Doctor

ULiège
" Using digital fabrication machines (laser cutter, 3D printing), the Fablab of the Aerospace and Mechanical Engineering Department of the Université de Liège has produced protective solutions (mainly Protective Face Shields) to protect healthcares from aerosol projection. These protective solutions have been distributed to the caregivers in hospitals in the region of Liège. A multidisciplinary team (PhD students and technicians under the supervision of a academic professor) at the Fablab from the Aerospace and Mechanical Engineering Department of the Université de Liège (Belgium) has developed and produced emergency protective solutions against Covid-19 for hospitals and caregivers. Most of these solutions have been developed using digital fabrication machines (laser cutter, 3D printers,...). We have produced mainly Protective Face Shields to protect caregivers from aerosol projection. A few thousand protections have been produced and distributed to caregivers from the CHU of...

Read more: Pierre Duysinx, Professor - Simon Bauduin - Pablo Alarcon - Trillet Denis - Joffrey Coheur - Laura...

UCLouvain - FNRS 
" Large-scale survey on the evolution of alcohol consumption / addictive behaviors (in the general population and in at-risk groups) during the COVID-crisis/lockdown period, and its links with environemental and psychological factors. "
Funding: None
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

UCLouvain - UNamur
" One of the key determining factors in viral infection is the entry of the virus into the host cells. Different CoVs including MHV, SARS-CoV and MERS-CoV have been consistently demonstrated to engage the endocytic pathway as the main mechanism for viral entry into a variety types of host cells. At present, the entry mechanisms and the implication of the endocytic pathway of the new emerging SARS-CoV-2 have not been reported directly. It is known that SARS-CoV-2 utilizes the same receptor of SARS-CoV, which is angiotensin converting enzyme II (ACE2) for viral entry into the host cells. Since SARS-CoV-2 also binds to the same ACE2 receptor as SARS-CoV it is highly possible that this new CoV utilizes the same endocytic pathway for entry into the host cells. Besides, a recent report suggests that SARS-CoV-2 invaded host cells via another route of CD147-spike protein. Our lab is studying the endocytosis mechanism of several plasma membrane receptors previously...

Read more: Pierre Morsomme, Professor - Henri-François Renard, Professor

UCLouvain
" www.covidata.be We gather data about the Coronavirus in Belgium, and attempt to extract meaningful information from it. We use open and/or public data to enable these analyses. "
Funding: No funding
Publication References: Work in progress
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.