Hôpital Erasme and ULB - Faculty of medicine
" A translational prospective research project was initiated to characterize longitudinally the immune responses of patients with COVID-19, to identify the mechanisms underlying progression to severe disease. Blood samples are collected at three different time points from two groups of patients, those with a flu-like disease, and those with respiratory symptoms (mild to severe). They are stored in a biobank after appropriate treatment to be further available for different research projects. The first one will focus on the characterization of the phenotype of innate cells (dendritic cells, monocytes, NK cells) and T lymphocyte subpopulations, and on the analysis of the concentrations of IFN-a and a panel of other cytokines, to investigate the importance of the kinetic of pDC mobilization and type I IFN production before the appearance of the cytokine storm. "
Funding: - ULB - COVID-19 special call - FNRS - crédit urgent de recherche...

Read more: Françoise Mascart, Professor - Véronique Del Marmol, Professor - Véronique Corbière, Doctor

AMB Ecosteryl
" AMB Ecosteryl (Mons), specialized in the treatment and sterilization of medical waste, has adapted its technology to develop a machine that decontaminates these masks (and therefore reuse them afterwards). This machine, named "M-steryl", allows, thanks to dry heat, to decontaminate 1.400 masks per day. This machine can easily be installed in hospitals, allowing staff to decontaminate their equipment individually. It requires only a power outlet and is easy to use. Each mask can be decontaminated three times, allowing for greater autonomy in terms of supply and lower costs. "
Contact: http://ecosteryl.com

ULiège, CHU - FNRS
" We aim to define the clinical characteristics associated with the production and the level of neutralizing antibodies (NAbs) in COVID19 recovered patients. In particular, we will investigate whether the development of a strong and persistent humoral immune response takes place in severely affected, individuals with mild symptoms or asymptomatic individuals. We will also study the study the persistence of NAbs overtime. "
Funding: Fonds Léon Frédéricq FNRS
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

ULiège, CHU
" La recherche de biomarqueurs fiables, sensibles et peu invasifs est un enjeu de premier ordre pour la médecine moderne. En effet, ces biomarqueurs ont le potentiel de transformer la prise en charge médicale en améliorant le dépistage et le diagnostic, mais aussi en permettant de mieux appréhender la physiopathologie d'une pathologie ou sa réponse à un traitement donné. Fort de nos travaux précédents, nous proposons de réaliser une étude prospective sur une population adulte souffrant d'un SDRA modéré à sévère post SARS-COV2 afin de caractériser une signature exosomique plasmatique propre à cette population. "
Funding: FLF FIRS CHU de Liège
Publication References: hankar-Hari, M., Fan, E. & Ferguson, N. D. Acute respiratory distress syndrome (ARDS) phenotyping. Intensive Care Med. (2018). 45;(4): 516-519. Thompson BT, Chambers RC, Liu KD. Acute Respiratory Distress Syndrome. N Engl J Med. 2017;377(6):562–72. Johnstone RM, Adam M, Hammond JR, Orr L, Turbide C. Vesicle...

Read more: Gilles Parzibut, Doctor

UCLouvain
" This research project aims at studying the conditions under which the modern welfare state could build a kind of epidemics insurance, while paying a particular attention to the issue of fairness. The global objective of saving lives may be associated to policies that have undesirable distributive effects, against ideals of social justice. The project aims at finding ways to make mass prevention and equity compatible. "
Funding: This project will be part of my research load at UCLouvain, within the Hoover Chair in Economic ans Social Ethics.
Publication References: Fleurbaey, M., Ponthiere, G. (2013). Prevention against Equality ? Journal of Public Economics. Fleurbaey, M., Leroux, ML, Ponthiere, G. (2014). Compensating the dead. Journal of Mathematical Economics. Fleurbaey, M., Leroux, ML., Pestieau, P., Ponthiere G. (2016). Fair retirement under risk lifetime. International Economic Review. Leroux, ML., Ponthiere, G. (2018). Working time regulations, unequal lifetime and...

Read more: Gregory Ponthiere, Professor

Univercells
" The current COVID19 pandemic has imposed in a few months a global burden on humanity. A vaccine is urgently needed to protect people, communities, healthcare systems, and economies. In this context, Univercells joined forces with Reithera and Leukocare to develop and manufacture a novel adenovirus-based vaccine against COVID19. This vaccine candidate is expected to enter in clinical trials during summer 2020 and production to start soon after. Capitalizing on the bioproduction technologies of its newly created subsidiary Univercells Technologies, Univercells will produce at large-scale the vaccine candidate in Jumet. This site with 15,000 m² GMP capabilities offers the capacity to be ready for rapid response programs. Approximately 6 million doses are expected to be available in early 2021. The intention with these doses will be to vaccinate the most exposed people such as medical and healthcare professionals and highly vulnerable individuals. "
Publication References...

Read more: Hugues Bultot, CEO

ULB, Department of Pathology, Erasme hospital and DIAPath-CMMI - Royal Academy of Medicine of Belgium
" A first objective of this project is to establish an accurate topography of the SARS-CoV-2 virus in the organs and various cells of patients who died in COVID-19 units, in order to contribute to a better understanding of the pathogenesis of COVID-19. A second objective is to provide a routine diagnostic test for the detection of SARS-CoV-2 in routine samples in pathological anatomy. "
Funding: Fonds Y Boël (Brussels, Belgium), Fonds Erasme pour la Recherche Médicale (Brussels, Belgium), and "Appel à projet Spécial COVID-19 - ULB" (Brussels, Belgium). The CMMI is supported by the European Regional Development Fund and the Walloon Region of Belgium (Wallonia-biomed; grant no. 411132-957270; project "CMMI-ULB").
Contact: Prof. I. Salmon, Department of Pathology, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik 808, 1070 Brussels, Belgium.

UMONS/Epicura
" We set up a pilot study including positive COVID-19 patients hospitalized in intensive care with acute renal disorders. The primary intention here is to assess the serum and urine metabonomic profiles of patients with renal disorders following SARS COV-2 infection at the time of their hospitalization in order to identify metabolic indicators of the acute renal injury. "
Funding: internal funding and CUR/FNRS project submitted
Publication References:
1. Lindon JC, Nicholson JK, Holmes E, Antti H, Bollard ME, Keun H, Beckonert O, Ebbels TM, Reily MD, Robertson D, Stevens GJ, Luke P, Breau AP, Cantor GH, Bible RH, Niederhauser U, Senn H, Schlotterbeck G, Sidelmann UG, Laursen SM, Tymiak A, Car BD, Lehman-McKeeman L, Colet JM, Loukaci A, Thomas C. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project. Toxicol Appl Pharmacol. 187(3):137-46 (2003)
2. Colet Jean-Marie, ""Metabonomics in the Preclinical and...

Read more: Jean-marie Colet, Pr. - Anne-Emilie Declèves, Pr. - Frédéric Debelle, Dr

Equaly sa
" Novel methods to prevent and treat Covid-19 viral infection by inhibiting virus entry "
Funding: not disclosed 

Equaly sa
" A novel strategy to prevent virus entry through the ACE2R A novel strategy for preventive vaccination to Covid-19 Monoclonal antibodies targeting the ACE2R are used to block virus entry. Vaccines are prepared eliciting a Th1response together with cytotoxic T cells. "
Funding: private
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

UCLouvain - FNRS
" In collaboration with the University of Rwanda, pro-inflammatory and anti-inflammatory cytokines will be measured in the plasma of COVID-19 patients and their level will be correlated with the severity of the disease. "
Funding: ARES-CCD
Publication References: Ndoricyimpaye EL, Tuyishimire J, Vanwambeke S, Mutesa L, Nyandwi E, Rujeni N, Coutelier J-P. L'épidémie de SARS-CoV-2 en Afrique sub-Saharienne, questions, craintes et espoirs. Louvain Médical, submitted.
Contact: Prof. J.-P. Coutelier de Duve Institute Universite Catholique de Louvain SSS/DDUV - ICP Av. Hippocrate 75, bte B1.74.05 1200 Woluwe-Saint-Lambert, Belgique tel 32 2 764 7437 fax 32 2 764 7430 e-mail This email address is being protected from spambots. You need JavaScript enabled to view it.

UCLouvain - FNRS
" In collaboration with the Central University of Ecuador, pro-inflammatory and anti-inflammatory cytokines will be measured in the plasma of COVID-19 patients and immunology pathways markers will be analysed by PCR. These results will be correlated with the severity of the disease. "
Funding: Requested to FNRS
Contact: Prof. J.-P. Coutelier de Duve Institute Universite Catholique de Louvain SSS/DDUV - ICP Av. Hippocrate 75, bte B1.74.05 1200 Woluwe-Saint-Lambert Belgique tel 32 2 764 7437 fax 32 2 764 7430 e-mail This email address is being protected from spambots. You need JavaScript enabled to view it.
Comment: This project is pending

Aesculape CRO Belgium BV
" Treatment of COVID 19 complications with antibodies "
Funding: partly public partly private
Contact : This email address is being protected from spambots. You need JavaScript enabled to view it. 0492 735931

UMONS, ULB, Sciensano
" A new type of biosensor to characterize in details antibodies specific for antigens of SARS-COV-2. "
Funding: UMONS
Publication References: E. Gosselin, O Denis, A. Van Cauwenberge, J. Conti, JJ Vanden Eynde, K. Huygen, J. De Coninck, "Quantification of the trichothecene Verrucarin-A in environmental samples using an antibody-based spectroscopic biosensor", Sensor Actuat. B.-Chem., 2012, 166-167, 549-555.
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

DELTRIAN
" Deltrian has developed four complete production lines for surgical masks (production and packaging) which will be operational in Fleurus from the end of May 2020. Deltrian will produce 160 surgical masks per minute following a work divided into two breaks. That is a total of 60 million masks per year. A shift to three breaks could even increase production to 90 million masks per year. In response to a request from the federal government and together with the company Sioen (Ardooie, West Flanders), Deltrian will also have the task of producing 20 million filters that will be used to improve the quality of cloth masks that will be compulsory to wear on public transport from 4 May 2020. This is part of a desire to repatriate certain know-how to Wallonia and is an integral part of the Region's reindustrialisation strategy. "
Contact: http://www.deltrian.com/