Hôpital Erasme and ULB - Faculty of medicine
" A translational prospective research project was initiated to characterize longitudinally the immune responses of patients with COVID-19, to identify the mechanisms underlying progression to severe disease. Blood samples are collected at three different time points from two groups of patients, those with a flu-like disease, and those with respiratory symptoms (mild to severe). They are stored in a biobank after appropriate treatment to be further available for different research projects. The first one will focus on the characterization of the phenotype of innate cells (dendritic cells, monocytes, NK cells) and T lymphocyte subpopulations, and on the analysis of the concentrations of IFN-a and a panel of other cytokines, to investigate the importance of the kinetic of pDC mobilization and type I IFN production before the appearance of the cytokine storm. "
Funding: - ULB - COVID-19 special call - FNRS - crédit urgent de recherche
Publication References: Dirix V, Corbiere V, Wyndham-Thomas C, Selis E, Allard S, Hites M, Aerts L, Giese T, Mascart F. Blood tolerogenic monocytes and low proportions of dendritic cell subpopulations are hallmarks of human tuberculosis. J. Leukoc. Biol. 2018; 103(5) : 945-954.
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