Votre navigateur ne supporte pas le javascript Wallonia & Brussels against COVID-19 - See all

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Sophie Vanwambeke, Professor - Catherine Linard, Professor - Marius Gilbert, FNRS Senior Research Associate - Simon Dellicour, FNRS Postdoctoral Researcher

ULB, UCLouvain, UNamur - FNRS
" Since early March, we have monitored spatial features of the epidemic, and various possible spatial determinants of its progression, including demographic, socio-economic and environmental indicators. We are also investigating the predictive and explanatory value of various indicators of mobility. Since the beginning of the covid-19 pandemic in Belgium, we observed strong spatial patterns in the disease case incidence. Before confinement measures came into effect mid-March, spatial predictors such as population density, as expected, were correlated to incidence. After the confinement came into effect, many such predictors no longer affected recorded incidence. We have assembled a rich database of demographic, socio-economic, and environmental indicators at the municipality level to identify spatial correlates of disease transmission. These are expected to differ pre- and through confinement, and to change further after confinement. We are also working...

Souad Rahmouni, Doctor

GIGA-Institute, ULiège - FNRS - Royal Academy of Sciences, Letters and Fine Arts of Belgium
" The main objective of our research program is the identification of human genetic factors impacting the COVID19 pandemic. Within the COVID-19 host genetics initiative (https://www.covid19hg.org/), we will establish a shared set of phenotypes to be combined with genomic data for standard GWAS and further meta-analysis. Field of expertise of our laboratory : genetics, genomics, bioinformatics, immune-response related diseases. In addition, the GIGA Institute is an interdisciplinary research institute from the ULiege devoted to academic excellence in the biomedical sciences to foster ground-breaking medical innovation. It comprises 583 members attached to six faculties (Medicine, Science, Veterinary Medicine, Engineering, Agbiotech, Psychology) that are organized in four disease-based (neuroscience, cancer, infection-inflammation-immunity, cardiovascular) and two method-based thematic units...

Stefan Constantinescu, Professor

UCLouvain - Royal Academy of Medicine of Belgium

Determination of Germ-Line Variations and Pathological Gene Expression that May Contribute to Immunopathology in COVID-19." The SARS-CoV-2 infection (1, 2), can be followed by a severe evolution with severe respiratory distress. We hypothesize that germline variants in genes involved in innate immunity, especially type I interferon induction and actions, predispose to delayed pathological response/cytokine storm. Our aims are to identify: i) such germ-line variants and ii) peripheral leukocyte gene expression that can predict unfavorable SARS-CoV2 infections. A group of SARS-CoV2 patients with unfavorable evolution, young and without co-morbidities (25) will be compared with an aged matched group of 25 SARS-CoV2 individuals with absence or a minimum of symptoms. Germ line DNA obtained from peripheral blood (PB) will be whole exome sequenced (WES) and analyzed with bioinformatics tools that are used for rare disease germline...

Timoteo Carletti, Full Professor

UNamur
" Understanding the evolution of the epidemic spreading using simple mathematical models to overcome of the biaises in the data "
Funding: UNamur
Publication References: https://www.researchgate.net/publication/340610501_UPDATE_Italy_now_two_weeks_past_the_peak
Contact: This email address is being protected from spambots. You need JavaScript enabled to view it.

Virginie Montiel, Professor

UCLouvain
" To confirm endothelial dysfunction in severe covid-19 patients admitted in Intensive Care Unit "
Funding: actually private; but waiting answer for credit urgent de recherche by FNRS
Publication References: 1) Manoury B, Montiel V, Balligand JL (2012). Nitric oxide synthase in post-ischaemic remodelling: New pathways and mechanisms. Cardiovascular Research, 94(2), 304-315. 2) Montiel V, Leon Gomez E, Bouzin C, Esfahani H, Romero Perez M, Lobysheva I, Balligand JL (2014). Genetic deletion of aquaporin-1 results in microcardia and low blood pressure in mouse with intact nitric oxide-dependent relaxation, but enhanced prostanoids-dependent relaxation. Pflugers Archiv European Journal of Physiology, 466(2), 237-251. 3) Montiel V, Robinson E, Bella R, Michel L, Esfahani H, De Mulder D, Deglasse JP, Jonas JC, Steinhorn B, Michel T, Beauloye C, Bertrand L, Farah C, Dei Zotti F, Bouzin C, Brusa D, Bergmann O, Gilis D, Rooman M, Roderick L, Devuyst O, Balligand JL. Cardiac...

Wim Laurier, Chargé de cours

USL-B 
" The pharmaceutical industry is confronted with many different issues at the levels of logistics and supply chain management. Traceability is a paramount in the pharmaceutical sector. It is not only essential to ensure the quality of the product, but also, it is required to trace possible adverse reactions back to a given lot of drug product, its manufacturing and control. Traceability needs to be addressed at three stages. First, the source (supplier) and origin (e.g. chemical, microbiological, animal, human…) of raw and starting materials must be identified. These materials must be tested and found compliant with compendial requirements. Second, traceability must be ensured in-house, throughout the all manufacturing process, from starting materials to the drug product, through the drug substance and all intermediates. Third, traceability should be ensured downstream, from lot release by the company to patient's administration. Traceability within the industry (stage 2) is...

Yves Crama, Professor - Gentiane Haesbroeck, Professor - Jean-Marc Minon, Doctor - Michaël Schyns, Professor

ULiège and Centre Hospitalier Régional de la Citadelle (service de biologie clinique)
" Data have been collected by the clinical laboratory of the regional hospital on Covid-19 infected patients who needed hospitalisation in March-April 2020. Using these data collected on the day of admission, data mining techniques have been applied in order to determine whether it is possible to classify the patients into one out of two groups corresponding to a favorable or an unfavorable evolution. "
Contact: M. Schyns (This email address is being protected from spambots. You need JavaScript enabled to view it.) G. Haesbroeck (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Contact us

c/o F.R.S. - FNRS

Rue d’Egmont 5

B - 1000 Bruxelles

Tél : +32 2 504 92 11

info@COVID19-WB.be

Brussels & Wallonia against COVID19