" The main scientific question of this project aims to understand this inter-individual variability in the response to 2019-nCoV in human population, first during ageing process, second among population of same age. The first hypothesis that will be tested in this project is that epigenetic differences among human population can, at least partly, explain differences in the individual responses to SARS-CoV-2, and that this virus differentially affects the epigenome of different individuals during the infection. The second hypothesis that will be tested is that changes in the epigenome during ageing could increase the susceptibility of patients to SARS-CoV-2. "
Funding: To be searched
Publication References: - Fellous A, Earley RL, Silvestre F. Identification and expression of mangrove rivulus (Kryptolebias marmoratus) histone deacetylase (HDAC) and lysine acetyltransferase (KAT) genes. Gene, 691 (2019), 56-69. - Fellous A, Earley RL, Silvestre F. The Kdm/Kmt gene families in the self-fertilizing mangrove rivulus fish, Kryptolebias marmoratus, suggest involvement of histone methylation machinery in development and reproduction. Gene 687 (2019), 173-187. - Falisse E, Ducos B, Stockwell PA, Morison IM, Chatterjee A, Silvestre F. DNA methylation and gene expression alterations in zebrafish early-life stages exposed to the antibacterial agent triclosan. Environmental Pollution. 2018 Oct;243:1867-1877. - Fellous A, Labed-Veydert T, Locrel M, Voisin A-S, Earley RL, Silvestre F. DNA methylation in adults and during development of the self‐fertilizing mangrove rivulus, Kryptolebias marmoratus. Ecology and Evolution. 8 (2018), 6016-6033. - Dorts J, Falisse E, Schoofs E, Flamion E, Kestemont P, Silvestre F. DNA methyltransferases and stress-related genes expression in zebrafish larvae after exposure to heat and copper during reprogramming of DNA methylation. Scientific Reports. 2016 Oct 12;6. 34254.
Frédéric Silvestre, Professor