FARAH - ULiège
" We are describing the evolution of the respiratory function after infection using whole-body plethysmography in a hamster model of SARS-CoV-2 pneumonia. Although the tropism of the virus for the upper respiratory tract is well documented, little is known about the pathophysiological mechanisms involved in the impairment of the respiratory function and the development of acute respiratory distress syndrome (ARDS) in some patients. There is a critical need for the development of noninvasive evaluation tools of the respiratory function over the disease course in order to develop therapeutic strategies aiming at specifically improving this function. Plethysmography is a noninvasive method allowing the quantitative evaluation of the lung volume and function. The selected plethysmographic parameters will allow a noninvasive monitoring of the lung function and lesions in the hamster model, permitting the screening of therapeutic molecules aiming at alleviating the respiratory dysfunction after SARS-CoV-2 infection. "
Funding: No funding. We applied to the "Crédits urgents de recherche" call.
Contact: Professor Daniel Desmecht Department of Pathology Faculty of Veterinary Medicine Centre for Fundamental and Applied Research for Animals & Health (FARAH) Liège Université Quartier Vallée 2 Avenue de Cureghem 6 (B43) B-4000 Liège (Belgium) Phone: +3243664075 e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.